Important: Please note: Due to a national holiday in Bulgaria, orders placed after 10 AM (UK time) on March 1st will ship on March 5th. The CFN Team

Efferalgan Rectal Suppositories 80mg 10 Pieces

Efferalgan Rectal Suppositories 80mg 10 Pieces

Efferalgan Rectal Suppositories 80mg 10 Pieces


Efferalgan, contains paracetamol with analgesic and antipyretic properties. The form of rectal suppositories allows for a quick effect and high efficiency of the drug.


Efferalgan rectal suppositories Composition:


1 suppository contains 80 mg, 150 mg or 300 mg of paracetamol.


Efferalgan rectal suppositories Action:


The drug has an analgesic and antipyretic effect, mainly by inhibiting the activity of prostaglandin cyclooxygenase in the CNS. It is well absorbed by the gastrointestinal tract, reaches its maximum concentration in the blood after about 20-60 minutes, penetrates into bodily fluids and internal organs, and about 25% of it is bound to plasma proteins. T 0.5 is 2-3 hours. It is metabolized in the liver, under the effect of microsomal enzymes there; excreted in the urine in the form of glucuronates and sulfates and after conjugation with cysteine. In patients with renal failure, conjugated paracetamol accumulates in the blood. After high doses, N-acetyl-p-benzoquinone is produced in the body, which is likely to cause liver damage.


Efferalgan rectal suppositories Indications:


Symptomatic treatment of pain and fever.


Contraindications:


Hypersensitivity to the drug (rare), congenital deficiency of G-6-PD and methaemoglobin reductase. Caution should be exercised in patients with bronchial asthma, allergic to acetylsalicylic acid and in the case of repeated doses in patients with severe hepatic impairment. It should not be used in children under 3 months of age.


Adverse reaction:


There are isolated cases of haematological disorders caused by long-term use (thrombocytopenia with symptoms of thrombocytopenic purpura) and allergic skin reactions (urticaria, erythema, itching, rash). When used in high doses or for a long time, it may impair liver function.


Interactions:


Paracetamol does not alter the bleeding time and platelet aggregation in healthy and haemophilic patients. Use with drugs that inhibit the breakdown of paracetamol in the liver (rifampicin, antiepileptics, some sleeping drugs) increases the risk of liver damage, with lamotrigine or chloramphenicol - it lowers their concentration in the blood. Cimetidine, metyrapone, probenecid, antipyrine, salicylamide, isoniazid, ranitidine, propranolol - prolongs the half-life of paracetamol in the blood.


Dosage:


In children under 3 months of age: paracetamol can only be used after consulting with a doctor. Recommended for children over 3 months of age: 10-15 mg / kg x 4 times a day, in some cases every 4 hours - this treatment can be continued for up to 3 days. Do not exceed the daily dose of 60 mg / kg. Adults and adolescents over 15 years of age: 600 mg x 1-4 times a day. Do not exceed a dose of 3.0 g per day. There should be an interval of at least 4 hours between doses. In case of severe renal failure (creatinine clearance below 10 ml / min), the dose intervals should be at least 8 hours.


Write a review

Note: HTML is not translated!
    Bad           Good

Captcha
  • Brand: UPSA
  • Product Code: Efferalgan-Rectal-Suppositories-80mg-10-Pieces
  • Availability: In Stock
  • £2.99
  • Ex Tax: £2.99

Express delivery?

Next day delivery: UK -  £15.99 | EU - £19.99 | Rest of the world - £24.99  

Tags: Efferalgan, Rectal, Suppositories, 80mg, fever, children