Neurobex x 150 Tablets

NEUROBEX x 150 TABLETS

What is Neurobex and what it is used for

Neurobex is a combined product containing B vitamins. They constitute the enzymes (enzymes) that help the metabolism of carbohydrates, fats and proteins. The combination of vitamins of group B is used to improve a number of important processes and functions in the body, and mainly to influence the inflammatory and degenerative processes (due to a change in the structure of the tissues where their viability is reduced), diseases of the nerves and joints.

When should you use Neurobex?

Neurobex is applied in complex treatment of the following diseases and conditions:

• Inflammatory and degenerative processes affecting peripheral nerves - neuritis, polyneuritis, neuralgia, myalgia, paresthesia (numbness and tingling in the extremities);
• Conditions of prolonged convalescence (recovery after prolonged illness), chronic alcoholism, poisoning, asthenia (fatigue and weakness);
  Vitamin B deficiency (conditions with reduced content in the body of B vitamins), skin disorders such as dermatitis, eczema, psoriasis, exudative diathesis, acne.

What you should know before using Neurobex

Do not take Neurobex:

• If you are allergic (hypersensitive) to the active substances or any of the other ingredients of this medicine (listed in section 6);
• If you have acute thromboembolism (obstruction of a court of clot formation); If you suffer from erythrosis and eritremiya (blood diseases with an increased number of red blood cells).

Warnings and Precautions

• Neurobex should be used with caution in patients with severe and acute forms of decompensated heart failure (heart disease, which can lead to fatigue, shortness of breath, swelling of the ankles, etc.) and angina.

Other medicines and Neurobex

Tell your doctor or pharmacist if you are using, have recently used or might use other drugs.
Ethanol (alcohol) dramatically reduces the absorption of vitamin B1.
Vitamin B6 affects the degradation of some drugs in the body. High doses of vitamin B6 reduce the effect of levodopa (a drug for the treatment of Parkinson's disease). This vitamin increases the conversion of levodopa, and reduces the therapeutic efficacy. Vitamin B6 antagonizes the action of isoniazid (antitubercular drug) and thiosemicarbazone (antivirals); correct anemia caused by antituberculosis agents. The continued intake of penicillamine (antirheumatic drug) can cause vitamin B6 deficiency. Concomitant administration of vitamin B6 with hydralazine (used to treat high blood pressure) and cycloserine (antitubercular drug) decreases adverse neurological effects associated with taking these drugs. The amount of vitamin B6 in the body decreases by concomitant contraceptives taken orally.
The absorption of vitamin B12 is inhibited by colchicine (for gout), ethanol and neomycin (antibiotic). Antidiabetics of the biguanidine type (eg. Metformin), and p-amino salicylic acid, as well as chloramphenicol (antibiotic) and Vitamin C, affect the absorption of vitamins.

Neurobex with food, drinks and alcohol

No evidence of the need for special diets or restrictions on certain types of foods and beverages during treatment with this product.
During treatment with this product alcohol should not be consumed as the contained therein ethanol reduces quantities of vitamin B1, which are absorbed through the intestines.

Pregnancy, lactation and fertility

If you are pregnant or breast-feeding, you think you may be pregnant or are planning to become pregnant, ask your doctor or pharmacist before taking this medicine.

Pregnancy
No evidence of fetal harm in applying Neurobex during pregnancy.
Due to insufficient data it is recommended to administer to pregnant women only when necessary.

Breastfeeding
No evidence of harm to the infant when applying Neurobex during lactation.
Due to insufficient data it is recommended that during this period it is applied only when necessary.

Driving and operating machines
It does not affect the ability to drive and operate machines.
Neurobex contains lactose monohydrate, wheat starch, E124
If your doctor has told you that you have an intolerance to some sugars, contact your doctor before taking this product.
Wheat starch in the composition of the product is suitable for people with celiac disease (gluten enterapiya). Patients with wheat allergy (different from celiac disease) should not take this product.
Colourant E124 may cause allergic reactions.

How to take Neurobex
Always use this medicine exactly as described in this leaflet. If you're not sure, ask your doctor or pharmacist.
The usual dose is 2-3 tablets x 3-4 times daily. Neurobex is to be taken orally. Tablets should be taken during or after a meal, without chewing, with a sufficient amount of liquid.

If you take more than the recommended dose of Neurobex
When taking a higher dose than recommended contact a doctor for advice.
Overdose leads to an increase in adverse reactions to the product. Some of the possible reactions include: nervous agitation, palpitations, chest pain. Treatment includes gastric lavage, activated charcoal, symptomatic treatment. Isoniazid is an antidote (antidote) of vitamin B6.

If you forget to take Neurobex
Do not take a double dose to make up for a missed dose. If you miss a dose, take it at the next regular intake without dose escalation.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

Possible side effects
Like all medicines, Neurobex can cause side effects, although not everybody gets them.
Neurobex is well tolerated by patients. In rare cases, it is possible to observe an increased tendency of sweating, palpitations, pruritus, urticaria (hives). In rare cases there may occur allergic reactions, rashes, shortness of breath, anaphylaxis (severe life-threatening allergic reaction).
There are reports of serious damage to sensory nerves in patients receiving high doses of vitamin B6 for 2 to 40 months. Such damage may occur during prolonged intake at lower doses.

If any of the side effects gets serious, or you notice other effects not listed in this leaflet, please tell your doctor or pharmacist.

How to store Neurobex
At temperatures below 25 ° C.
Keep out of reach of children.
Do not use Neurobex after the expiry date stated on the carton. The expiry date refers to the last day of that month.
Do not use Neurobex if you notice changes in the appearance of the tablets.
Do not dispose of medications in wastewater or household waste. Ask your pharmacist how to dispose of medicines you no longer use. These measures will help protect the environment.

Contents of the pack and other information

The active substances are: thiamine nitrate (vitamin B1) 15 mg, pyridoxine hydrochloride (vitamin B6) 10 mg, cyanocobalamin (vitamin B12) 0,02 mg.
The other ingredients are lactose monohydrate, corn starch, talc, magnesium stearate, silica colloidal anhydrous, povidone.
Film Coating: kolikoat Protect, titanium dioxide, talc, dye E124.