Ruvexin 325mg 100 tablets

Ruvexin 325mg 100 tablets

WHAT IS RUVEXIN? Treatment of aches and pains associated with headache, common cold, sore throat and for reduction of fever. It may be used to reduce the risk of death and lessen the damaging effects of an acute heart attack. It is also used to reduce the risk of heart attacks and strokes in certain men and women who have already had a heart attack or ischemic stroke. It may also be used for other conditions as determined by your doctor. Ruvexin is a nonsteroidal anti-inflammatory drug (NSAID). It works by inhibiting several different chemical processes within the body that cause pain, inflammation, and fever. It also reduces the tendency for blood to clot. 

An indication is a term used for the list of conditions, symptoms or illnesses for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy, meaning without a prescription by the physician.

Ruvexin is indicated to: Reduce the risk of death and myocardial infarction (MI) in patients with chronic coronary artery disease, such as patients with a history of MI or unstable angina pectoris or with chronic stable angina. Reduce the risk of death and recurrent stroke in patients who have had an ischemic stroke or transient ischemic attack.

Limitation of Use: Use immediate-release aspirin, not Ruvexin in situations where a rapid onset of action is required (such as acute treatment of myocardial infarction or before percutaneous coronary intervention).

HOW SHOULD I USE RUVEXIN? Use Ruvexin as directed by your doctor. Check the label on the medicine for exact dosing instructions. Take Ruvexin by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation. Take Ruvexin with a full glass of water (8 oz/240 mL). Use Ruvexin exactly as directed on the package, unless instructed differently by your doctor. If you are taking Ruvexin without a prescription, follow any warnings and precautions on the label. If you take bisphosphonates (eg, alendronate), cation exchange resins (eg, sodium polystyrene), cephalosporins (eg, cefpodoxime), imidazole antifungals (eg, ketoconazole), penicillamine, quinolone antibiotics (eg, ciprofloxacin), or tetracycline antibiotics (eg, doxycycline), do not take them at the same time you take Ruvexin. Talk with your doctor about how you should take these other medicines along with Ruvexin. If you miss a dose of Ruvexin and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Ask your healthcare provider any questions you may have about how to use Ruvexin. There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be discontinued after a few days, some drugs need to be continued for prolonged periods of time to get benefit from it.

This product is a combination of aspirin and an antacid (such as calcium carbonate, aluminum hydroxide, or magnesium oxide). The antacid helps reduce heartburn and upset stomach that aspirin may cause. Aspirin is used to reduce fever and relieve mild to moderate pain in conditions such as muscle aches, toothaches, common cold, and headaches. It may also be used to reduce pain and swelling in conditions such as arthritis. Aspirin is known as a salicylate and a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking a certain natural substance in your body to reduce pain and swelling. Consult your doctor before treating a child younger than 12 years of age. Your doctor may direct you to take a low dose of aspirin to prevent blood clots. This effect reduces the risk of stroke and heart attack. If you have recently had surgery on clogged arteries (such as bypass surgery, carotid endarterectomy, coronary stent), your doctor may direct you to use aspirin in low doses as a "blood thinner" to prevent blood clots. How to use Ruvexin If you are taking this medication for self-treatment, follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist. If your doctor has directed you to take this medication, take it exactly as prescribed. Take this medication by mouth. Drink a full glass of water (8 ounces/240 milliliters) with it unless your doctor tells you otherwise. Do not lie down for at least 10 minutes after you have taken this drug. If stomach upset occurs while you are taking this medication, you may take it with food or milk. The antacid in this product may react with other medications (such as digoxin, iron, tetracycline antibiotics, quinolone antibiotics such as ciprofloxacin), preventing them from being fully absorbed by your body. Talk with your doctor or pharmacist about how to schedule your medications to prevent this problem. The dosage and length of treatment are based on your medical condition and response to treatment. Read the product label to find recommendations on how many tablets you can take in a 24-hour period and how long you may self-treat before seeking medical advice. Do not take more medication or take it for longer than recommended unless directed by your doctor. Use the smallest effective dose. Consult your doctor or pharmacist if you have any questions. If you are taking this medication for self-treatment of headache, seek immediate medical attention if you also have slurred speech, weakness on one side of the body, or sudden vision changes. Before using this drug, consult a doctor or pharmacist if you have headaches caused by head injury, coughing, or bending, or if you have a headache with persistent/severe vomiting, fever, and stiff neck. If you are taking this medication as needed (not on a regular schedule), remember that pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medicine may not work as well. You should not take this medication for self-treatment of pain lasting for longer than 10 days. You should not use this drug to self-treat a fever that lasts longer than 3 days. In these cases, consult a doctor because you may have a more serious condition. Tell your doctor promptly if you develop ringing in the ears or difficulty hearing. If your condition persists or worsens (such as new or unusual symptoms, redness/swelling of the painful area, pain/fever that does not go away or gets worse) or if you think you may have a serious medical problem, tell your doctor promptly.


The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Ruvexin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)


Individual. For oral administration dosing of Ruvexin depends on the indication for use. Usual adult dose when used as antipyretic and analgesic is 500-1000 mg / day (up to 3 g), divided into 3 admission. In myocardial infarction, as well as for secondary prevention in patients after myocardial infarction - 40-325 mg 1 time a day (usually 160 mg). As an inhibitor of platelet aggregation - a dose of 300-325 mg / day, for a long period of time. At the dynamic circulatory disorders in men, cerebral thromboembolism, including to prevent a recurrence - 325 mg / day with gradual increase to a maximum of 1 g / day. For prevention of thrombosis or occlusion of the aortic shunt - by 325 mg every 7 h after intranasal gastric tube set, and then - through the mouth to 325 mg x 3 times a day (usually in combination with dipyridamole, which decomposed after 1 week, continues the long-term treatment with Ruvexin).


Simultaneous use of antacids containing magnesium and / or aluminum hydroxide can slow down and reduce the absorption of Ruvexin. Simultaneous use of calcium channel blockers, limits the intake of calcium or increases the excretion of calcium from the body, which increases the risk of bleeding. Simultaneous use with Ruvexin enhances the action of heparin and indirect anticoagulants, hypoglycemic provides derived sulfonylureas, insulin, methotrexate, phenytoin, valproic acid. Simultaneous use of Ruvexin with SCS increases the risk of ulcerogenic effects and occurrence of gastrointestinal bleeding. Simultaneous use decreases the effectiveness of diuretics (spironolactone, furosemide). Simultaneous use of other NSAIDs increases the risk of side effects. Ruvexin may reduce plasma concentrations when used with indomethacin, piroxicam. Simultaneous use of gold drugs can induce liver damage. Simultaneous use decreases effectiveness of uricosuric medications (including probenecid, sulfinpirazon, benzbromarone). Simultaneous use of Ruvexin and alendronate sodium may cause the development of severe esophagitis. Simultaneous use of griseofulvin may make absorption of Ruvexin more difficult. There is one case of spontaneous hemorrhage in the iris while taking Ginkgo Biloba extract after prolonged use of aspirin in a dose of 325 mg / day. It is believed that this may be due to the additive inhibitory effect on platelet aggregation. Simultaneous use of dipyridamole may increase Cmax of salicylate in the plasma and AUC. When applied simultaneously with Ruvexin, there is an increased concentration of digoxin, barbiturates and lithium salts in the blood plasma. Simultaneous use of salicylates in high doses with carbonic anhydrase inhibitors can cause salicylate intoxication. Ruvexin in doses of less than 300 mg has little effect on the effectiveness of captopril and enalapril. When aspirin (Ruvexin) is admistered in high doses it may decrease the effectiveness of captopril and enalapril. Simultaneous application of caffeine increases the rate of absorption, plasma concentrations and bioavailability of Ruvexin. Simultaneous use of Ruvexin with metoprolol may increase the Cmax of salicylate in blood plasma. During the application of pentazocine after long-term use of aspirin in high doses there is a risk of severe adverse reactions in the kidneys. Simultaneous application of phenylbutazone reduces uricosuria caused by Ruvexin. Simultaneous application of ethanol may exacerbate the effects of Ruvexin on the gastrointestinal tract.


Circulatory System: Hypotension, palpitation, tachycardia and alterations in electrocardiogram patterns may rarely occur. Nervous System: If drowsiness, dizziness, sleep disorder, headache, tremor or infrequently anaphrodisia, excitement, hypomnesis, oculogyric crisis, paresthesia, dysarthria and ataxia occur, the dosage should be reduced or Ruvexin should be discontinued. Hypersensitivity: If hypersensitivity symptoms eg, eruption occurs, Ruvexin should be discontinued. Hematologic Effects: If hemopathy eg, leukopenia occurs, Ruvexin should be discontinued. Hepatic Effects: The elevation of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, lactate dehydrogenase may occur. Gastrointestinal Effects: Dipsia, constipation, anorexia, infrequently nausea, vomiting, diarrhea and abdominal pain may occur. Endocrine System: Syndrome of inappropriate antidiuretic hormone (SIADH) eg, hyponatremia, hypotonic symptom, isosthenuria convulsion and clouding of consciousness have been reported in patients receiving a similar compound (amitrypsin). Other Adverse Reaction: Weariness, urinary retention and rhinocleisis may occur.


This medicine is contraindicated in the following situations: hypersensitivity to Ruvexin or any of the excipients; history of asthma provoked by the administration of salicylates or substances of similar activity, including anti-inflammatory drugs, PUD evolving any constitutional or acquired bleeding disorder, risk of bleeding, severe hepatic, severe renal insufficiency, uncontrolled severe heart failure, pregnancy beyond 24 weeks of gestation (5 months of age) at doses above 100 mg per day: beyond 24 weeks of gestation (5 months old), all inhibitors of prostaglandin synthesis may damage the fetus: a cardiopulmonary toxicity (ductus arteriosus and pulmonary hypertension), renal dysfunction may progress to renal failure associated with oligohydramnios. In late pregnancy, the mother and the newborn may experience: prolonged bleeding time due to an anti-platelet aggregation that may occur even after administration of low doses of medication inhibiting uterine contractions leading to a delay term or prolonged labor. Consequently, aspirin is not recommended beyond 24 weeks of gestation (5 months old), in combination with methotrexate in doses above 20 mg / week, in combination with oral anticoagulants for anti-inflammatory doses of Ruvexin (> 1 g per dose and / or <3 g per day), or analgesic or antipyretic doses (> = 500 mg per dose and / or <3 g per day) in a patient with a history of peptic ulcers. Due to the presence of lactose, the drug is contraindicated for congenital galactosemia, malabsorption of glucose and galactose deficiency or lactase. The use of this drug is not recommended during lactation: Ruvexin passes into breast milk,therefore this medicine is not recommended during breastfeeding. Concomitant use of Ruvexin, with anti-inflammatory medications (> 1 g per dose and / or <3 g per day), analgesics or antipyretics (> = 500 mg per dose and / or <3 g day), oral anticoagulants.

Active ingredient matches for Ruvexin: Acetylsalicylic Acid in Bulgaria. 

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  • Brand: PERRIGO
  • Product Code: Ruvexin-325mg-100-tablets
  • Availability: In Stock
  • £5.49
  • Ex Tax: £5.49

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Tags: myocardial infarction, ischemic stroke, blood